Date/Time: Thursday 7th March 2019 (Kick-off 6:55 PM CET).
There is no doubt that Sevilla have fallen off a cliff when it comes to their form in Spain, but this is a club that has a real affiliation with the Europa League and the two wins over Lazio in the Last 32 underlines their status as one of the favourites to win the competition this season too.
Five Europa League wins in thirteen years is an incredible achievement and it is beginning to look like Sevilla's best route back into the Champions League. Sevilla have been dominant at home in Europe, especially at the Europa League level, and they will believe that form can take them through to the Final in Baku in May.
In this season's competition Sevilla have won all 7 home Europa League games and 6 of those have come by at least a two goal margin. In recent weeks they have won 3 of their last 5 at home in all competitions and Sevilla have scored at least twice in each of those games which suggests they could have too much firepower for their visitors on Thursday.
Slavia Prague have to be respected as the leaders of the Czech top flight and after working their way through to the Last 16. This is their best run in any European competition for a number of years, but I can't ignore the fact that Slavia Prague have had their issues away from home in Europe already this season.
In fact Slavia Prague have lost 3 of their 5 away European ties in the 2018/19 season and 2 of the defeats suffered have come by two goal margins.
I do think that is the most likely outcome of the First Leg which will put Sevilla in control of the tie and I will back the Spaniards to cover the Asian Handicap.
Prediction: Sevilla -1.25 Asian Handicap