Southampton have all-but secured their Premier League status after a 1-0 win at relegation rivals Swansea last time out. The win put moved the Saints three points clear of the Swans.
However, the south coast side has a superior goal difference of nine, so there would need to be an extraordinary swing in the goal difference to see Mark Hughes side suffer relegation.
The Saints form has improved of late, as they are now unbeaten in four games in the Premier League. However, their form at St Mary's is still concerning, as the home side have won just once in ten outings on home soil in the league.
Manchester City heads into this clash with the chance to become the first team in Premier League history to break the 100-point mark.
The Citizens have coasted to the Premier League title this season and have an incredible goal difference of +78. While other teams may be complacent heading into this sort of clash, City boss Pep Guardiola is unlikely to let complacency creep into his team.
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Prediction
Away win and/or over 2.5 goals